Health state is constantly being defined by dynamic feedback control between self, non-self, external chemical stress, and psychoneurological stress both early in life through immune conditioning and during lifespan through innate and adaptive immune responses. The microbiome is both internally controlled and controlled by the immune system. Internal control of microbiota in the microbiome has been mathematically modeled using generalized Lotka-Volterra models of competition extensively. Mathematically modeling control of the microbiome by the immune system has been recently done for early life on a limited set of microbes and a single immune controller. Mathematically models of the feedback between the immune system and the microbiome largely lumps the entire microbiome into a single pathogenic plant. Here we propose a model of the microbiome control of the immune system using competitive Michaelis-Menten kinetics. The inhibitor concentration is proportional to a linear combination microbial species that have been identified in literature to inhibit specific immune cells. The activator concentration is proportional to a linear combination of microbial species that produce specific cytokines that either kill microbes directly via defensins or increase the nutrient diffusion length. This model was tested on a set of 34 microbial species commonly identified in the microbiome from firmicutes, bacteriodetes, actinobacteria, and proteobacteria. The immune system was defined to consist of a limited set of innate lymphoid cells (ILC1, ILC2, ILC3), macrophages, and Treg cells reducing the overall concentration of specific interleukins.
This seminar will be held in Grainger Hall room 1112 and online via Panopto.
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Both attendance options are free and open to all.
- Nicholas School of the Environment
- Integrated Toxicology & Environmental Health (ITEHP)